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The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation:  
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Swedish Defence Research Agency, Division of CBRN Defence and Security, SE-901 82 Umeå, Sweden.
Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK.
Biomedical Sciences Department, Defence Evaluation and Research Agency, Porton Down, Salisbury, Wiltshire SP4 OJQ, UK.
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1999 (English)In: Molecular Microbiology, ISSN 0950-382X, E-ISSN 1365-2958, Vol. 32, no 5, 961-976 p.Article in journal (Refereed) Published
Abstract [en]

Type III-mediated translocation of Yop effectors is an essential virulence mechanism of pathogenic Yersinia. LcrV is the only protein secreted by the type III secretion system that induces protective immunity. LcrV also plays a significant role in the regulation of Yop expression and secretion. The role of LcrV in the virulence process has, however, remained elusive on account of its pleiotropic effects. Here, we show that anti-LcrV antibodies can block the delivery of Yop effectors into the target cell cytosol. This argues strongly for a critical role of LcrV in the Yop translocation process. Additional evidence supporting this role was obtained by genetic analysis. LcrV was found to be present on the bacterial surface before the establishment of bacteria target cell contact. These findings suggest that LcrV serves an important role in the initiation of the translocation process and provides one possible explanation for the mechanism of LcrV-induced protective immunity.

Place, publisher, year, edition, pages
John Wiley & Sons, 1999. Vol. 32, no 5, 961-976 p.
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Cell Biology Biochemistry and Molecular Biology Microbiology Basic Medicine
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URN: urn:nbn:se:umu:diva-52999DOI: 10.1046/j.1365-2958.1999.01408.xPubMedID: 10361299OAI: oai:DiVA.org:umu-52999DiVA: diva2:508748
Available from: 2012-03-09 Created: 2012-03-09 Last updated: 2017-12-07Bibliographically approved

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Holmström, AnnaCarlsson, EvaWolf-Watz, Hans
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CiteExportLink to record
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