Ventricular endocrine and mechanical function following thrombolysis for acute myocardial infarction
2007 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 117, no 1, 51-58 p.Article in journal (Refereed) Published
Objective The objective of this study was to assess natriuretic peptide release following acute myocardial infarction, and its relationship with ventricular function. Methods A total of 44 patients with acute myocardial infarction were studied; 13 anterior, age (57 Â± 12Â years) and 31 inferior, age (58 Â± 12Â years). Peptide levels and left ventricular function by echocardiography were assessed at admission and on days 7 and 30 after thrombolysis. Healthy volunteers (n = 21) served as controls. Results Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) levels rose from admission to day 7 (p = 0.002). While ANP remained elevated at day 30 in both groups, BNP levels fell in patients with anterior myocardial infarction (p = 0.03). Left ventricular fractional shortening was reduced at admission in the two groups (p = 0.01) but returned towards normal in 7Â days (p = 0.001) in inferior myocardial infarction and in 30Â days in anterior myocardial infarction (p = 0.02). Left ventricular long axis amplitude was universally reduced at admission (p = 0.01) and remained abnormal at day 30 (p = 0.01) in both groups. At day 7, BNP and ANP levels inversely correlated with long axis amplitude of lateral wall in anterior myocardial infarction; (r = âˆ’ 0.7, p = 0.01). BNP correlated inversely with fractional shortening in anterior myocardial infarction (r = âˆ’ 0.7, p = 0.01) at day 30. Conclusion The elevated peptide levels at 7Â days post-myocardial infarction correlate with reduced mechanical activity of the adjacent noninfarcted segment. Natriuretic peptides release seem to be related to failure of compensatory hyperdynamic activity of the noninfarcted area rather than directly from the injured myocardial segments.
Place, publisher, year, edition, pages
2007. Vol. 117, no 1, 51-58 p.
Myocardial infarction, Ventricular function, Natriuretic peptides, Thrombolysis
IdentifiersURN: urn:nbn:se:umu:diva-53471DOI: 10.1016/j.ijcard.2006.04.052OAI: oai:DiVA.org:umu-53471DiVA: diva2:512516