umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Both El Tor and classical cholera toxin bind blood group determinants
Show others and affiliations
2012 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 418, no 4, 731-735 p.Article in journal (Refereed) Published
Abstract [en]

Cholera is a disease which shows a clear blood group profile, with blood group 0 individuals experiencing the most severe symptoms. For a long time, the cholera toxin has been suspected to be the main culprit of this blood group dependence. Here, we show that both El Tor and classical cholera toxin B-pentamers do indeed bind blood group determinants (with equal affinities), using Surface Plasmon Resonance and NMR spectroscopy. Together with previous structural data, this confirms our earlier hypothesis as to the molecular basis of cholera blood group dependence, with an interesting twist: the shorter blood group H-determinant characteristic of blood group 0 individuals binds with similar binding affinity compared to the A-determinant, however, with different kinetics. (C) 2012 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
San Diego: Elsevier, 2012. Vol. 418, no 4, 731-735 p.
Keyword [en]
Bacterial toxin, Blood group, Cholera, Host-pathogen interaction, NMR spectroscopy, Surface Plasmon Resonance/Biacore
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-53940DOI: 10.1016/j.bbrc.2012.01.089ISI: 000301332100025OAI: oai:DiVA.org:umu-53940DiVA: diva2:515180
Available from: 2012-04-12 Created: 2012-04-10 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Holmner, Åsa

Search in DiVA

By author/editor
Holmner, Åsa
By organisation
Radiation Physics
In the same journal
Biochemical and Biophysical Research Communications - BBRC
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 83 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf