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The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy
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2012 (English)In: Anticancer research, ISSN 1791-7530, Vol. 32, no 4, 1339-1346 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC).

Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (≥50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts.

Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75).

Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.

Place, publisher, year, edition, pages
The International Institute of Anticancer Research , 2012. Vol. 32, no 4, 1339-1346 p.
Keyword [en]
NSCLC, lung cancer, radiotherapy, predictive value, age
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-54263ISI: 000302492600028PubMedID: 22493368OAI: oai:DiVA.org:umu-54263DiVA: diva2:517253
Available from: 2012-04-23 Created: 2012-04-23 Last updated: 2012-05-18Bibliographically approved

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