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Derivatives of 8-hydroxyquinoline-antibacterial agents that target intra- and extracellular Gram-negative pathogens
Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Science and Technology, Department of Chemistry. (pa.enquist@chem.umu.se)
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden.
Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden.
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2012 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 22, no 10, 3550-3553 p.Article in journal (Refereed) Published
Description
Abstract [en]

Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-)methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure-activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 22, no 10, 3550-3553 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-54401DOI: 10.1016/j.bmcl.2012.03.096PubMedID: 22525317OAI: oai:DiVA.org:umu-54401DiVA: diva2:523734
Note

Available online 6 April 2012

Available from: 2012-04-26 Created: 2012-04-25 Last updated: 2017-12-07Bibliographically approved

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Enquist, Per-AndersGylfe, ÅsaSundin, CharlottaElofsson, Mikael
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Umeå Centre for Microbial Research (UCMR)Molecular Infection Medicine Sweden (MIMS)Department of ChemistryClinical Bacteriology
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Bioorganic & Medicinal Chemistry Letters
Biochemistry and Molecular Biology

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