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Mechanical force modulates scleraxis expression in bioartificial tendons
University of British Columbia, and Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
James Hogg Research Centre-St Paul’s Hospital, Vancouver;.
University of British Columbia, and Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver.
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2011 (English)In: Journal of Musculoskeletal and Neuronal Interactions - JMNI, ISSN 1108-7161, Vol. 11, no 2, 124-132 p.Article in journal (Refereed) Published
Abstract [en]

Following tendon injury, cartilage, bone and fat metaplasia are often observed, making the optimization of tenocyte differentiation an important clinical goal. In this study we examined the effect of static and cyclic mechanical loading on the expression of genes which play a role in tenocyte differentiation and function, namely scleraxis (Scx) and Type I collagen (Col1a1), and determined the effect of varying mechanical parameters including (1) static vs dynamic load, (2) increasing strain magnitude, (3) inclusion of 10 s rest periods, and (4) increasing cycle number. Cyclic loading resulted in a greater increase of tenocyte gene expression than static loading over 3 weeks in culture. Increasing strain levels potentiated the induction of tenocyte genes. The insertion of a 10 s rest periods further enhanced tenocyte gene expression, as did increasing repetition numbers. These results suggest that mechanical signaling exerts an important influence on the expression of genes which play a role in determining the tendon phenotype. Further work is required to confirm and extend these findings in primary cells such as resident tendon progenitor/stem cells, in order to provide an improved understanding of biology from which optimized rehabilitation programs can be developed.

Place, publisher, year, edition, pages
International Society of Musculoskeletal and Neuronal Interactions, 2011. Vol. 11, no 2, 124-132 p.
Keyword [en]
Tenocyte, Mechanotransduction, Tendinopathy
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-54507ISI: 000291698500006PubMedID: 21625049OAI: oai:DiVA.org:umu-54507DiVA: diva2:524061
Available from: 2012-04-27 Created: 2012-04-27 Last updated: 2017-12-07Bibliographically approved

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CiteExportLink to record
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Citation style
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