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A combined tactile and Raman probe for tissue characterization - design considerations
Luleå University of Technology.
Luleå University of Technology and Chalmers University of Technology.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Luleå University of Technology.
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2012 (English)In: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 23, no 6, 065901- p.Article in journal (Refereed) Published
Abstract [en]

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 °C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.

Place, publisher, year, edition, pages
Institute of Physics (IOP), 2012. Vol. 23, no 6, 065901- p.
National Category
Medical Engineering
URN: urn:nbn:se:umu:diva-55061DOI: 10.1088/0957-0233/23/6/065901OAI: diva2:525342
Available from: 2012-05-07 Created: 2012-05-07 Last updated: 2012-06-14Bibliographically approved

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Jalkanen, VilleLindahl, Olof A
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