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Anandamide uptake explained?
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
2012 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 33, no 4, 181-185 p.Article, review/survey (Refereed) Published
Abstract [en]

The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metabolism have been well characterised, the processes involved in uptake have been the subject of much controversy. Recent studies, however, have identified intracellular transport proteins (fatty acid binding proteins 5 and 7, heat shock protein 70, albumin, and fatty acid amide hydrolase-like AEA transporter protein) that shuttle AEA from the plasma membrane to its metabolic enzymes. Proteins such as the fatty acid amide hydrolase-like anandamide transporter protein may be useful targets for novel therapeutic strategies aimed at potentiating AEA signalling. In this article I review the current state of the art of endocannabinoid uptake.

Place, publisher, year, edition, pages
2012. Vol. 33, no 4, 181-185 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-55336DOI: 10.1016/ 000303100000002OAI: diva2:527304
Available from: 2012-05-19 Created: 2012-05-14 Last updated: 2012-05-19Bibliographically approved

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