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The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
2012 (English)In: Developmental Dynamics, ISSN 1058-8388, E-ISSN 1097-0177, Vol. 241, no 5, 984-994 p.Article in journal (Refereed) Published
Abstract [en]

Background: Neuronal circuit assembly comprises a number of developmental processes that ultimately underlie function. Identifying the molecular events that dictate these processes can give key insights into how neuronal circuit formation is coordinated. To begin to identify such molecular mechanisms, we have analysed the expression of a candidate gene of entirely unknown function within the nervous system. Here we reveal the spatial and temporal distribution of Lzts1 in mouse and chick embryonic spinal cord and propose potential biological functions. Results: Lzts1 mRNA is transiently expressed at the border of the ventricular and mantle zones in subsets of sensory and motor spinal neurons. The protein is localized to the cell body, axon, and trailing process of motor, commissural, and dorsal root neurons during development. Conclusions: Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons. Developmental Dynamics 241:984994, 2012. (c) 2012 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
2012. Vol. 241, no 5, 984-994 p.
Keyword [en]
Lzts1, spinal cord, axon guidance, cell cycle, mouse embryo, chick embryo, tumor suppressor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-55301DOI: 10.1002/dvdy.23777ISI: 000302861200014OAI: oai:DiVA.org:umu-55301DiVA: diva2:527321
Available from: 2012-05-19 Created: 2012-05-14 Last updated: 2017-12-07Bibliographically approved

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Wilson, Sara I.

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