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Pancreatitis in Hyperlipemic Mink (Mustela vison)
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
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2012 (English)In: Veterinary pathology, ISSN 0300-9858, E-ISSN 1544-2217, Vol. 49, no 3, 557-561 p.Article in journal (Refereed) Published
Abstract [en]

In both man and animals, inflammatory changes in the pancreas often occur with disturbances in lipid metabolism, including hypertriglyceridemia and an excess of free fatty acids. Hyperlipoproteinemia type I is a human condition caused by a deficiency of lipoprotein lipase. A similar metabolic disturbance that occurs in mink is of considerable comparative interest, as it is also followed by pancreatitis. Pancreatic lesions in hyperlipoproteinemic mink included overt variably sized nodules with hemorrhage and necrosis. These lesions began as intralobular necrosis of exocrine cells and progressed to total lobular destruction, with eventual involvement of interlobular tissue. Remnants of epithelial cells and lipid-filled macrophages were seen in necrotic areas, along with other types of inflammatory cells scattered in a lipid-rich exudate. Granulation tissue developed rapidly in necrotic areas. Additional observations included ductal proliferation, replacement of epithelial cells with fat, and mural arterial thickening, most conspicuously with vacuolated cells and endothelial proliferation. Extravasation of lipid-rich plasma is thought to be a major intensifier of the inflammatory response.

Place, publisher, year, edition, pages
Thousand Oaks, CA: Sage Publications, 2012. Vol. 49, no 3, 557-561 p.
Keyword [en]
hyperlipoproteinemia, lipoprotein lipase deficiency, mink, pancreatitis
National Category
Veterinary Science
URN: urn:nbn:se:umu:diva-55517DOI: 10.1177/0300985811417248ISI: 000303234900019OAI: diva2:528689
Available from: 2012-05-28 Created: 2012-05-21 Last updated: 2012-05-28Bibliographically approved

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Olivecrona, Gunilla
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