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ALK and NSCLC: targeted therapy with ALK inhibitors
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Palmer)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Hallberg)
2011 (English)In: F1000 medicine reports, ISSN 1757-5931, Vol. 3, 21- p.Article in journal (Refereed) Published
Abstract [en]

For many years treatment for advanced or metastatic non-small cell lung cancer (NSCLC) has employed chemotherapy regimens for patient care, with limited effect. Five-year survival rates for these patients are not encouraging. However, for a subgroup of these patients, there have been radical changes over recent years. Our understanding of the basic pathology behind NSCLC at the molecular level has offered up a host of new molecularly targeted therapies, which are revolutionizing this area of cancer care. Results from recent clinical trials provide hope for NSCLC patients harboring oncogenic translocations involving the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. Just as inhibition of the breakpoint cluster region-ABL complex has changed the face of chronic myeloid leukemia diagnosis, oncogenic ALK fusions offer a step forward in the diagnosis and treatment of ALK-positive NSCLC. This article discusses the current knowledge and potential implications concerning ALK inhibitors and NSCLC.

Place, publisher, year, edition, pages
2011. Vol. 3, 21- p.
National Category
Cell and Molecular Biology
URN: urn:nbn:se:umu:diva-55743DOI: 10.3410/M3-21PubMedID: 22076124OAI: diva2:529186
Available from: 2012-05-29 Created: 2012-05-29 Last updated: 2012-11-07Bibliographically approved

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Palmer, Ruth HHallberg, Bengt
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