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hTERT Cancer Risk Genotypes Are Associated With Telomere Length
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2012 (English)In: Genetic Epidemiology, ISSN 0741-0395, E-ISSN 1098-2272, Vol. 36, no 4, 368-372 p.Article in journal (Refereed) Published
Abstract [en]

Telomere biology is associated with cancer initiation and prognosis. Collected data suggest that blood cell telomere length (TL) can change over time, which may be related to development of common disorders, such as cardiovascular diseases and cancer. Recently, single nucleotide polymorphisms in the region of the human telomerase reverse transcriptase (hTERT) gene were associated with various malignancies, including glioma, lung and urinary bladder cancer, and telomerase RNA gene hTERC genotypes were recently linked to TL. In the present study a hypothetical association between identified genotypes in hTERT and hTERC genes and TL were investigated. We analyzed 21 polymorphisms, covering 90% of the genetic variance, in the hTERT gene, two genetic variants in hTERC, and relative TL(RTL) at average age 50 and 60 in 959 individuals with repeated blood samples. Mean RTL at age 60 was associated with four genetic variants of the hTERT gene (rs2736100, rs2853672, rs2853677, and rs2853676), two of which reported to be associated with cancer risk. Two alleles (rs12696304, rs16847897) near the hTERC gene were confirmed as also being associated with RTL at age 60. Our data suggest that hTERT and hTERC genotypes have an impact on TL of potential relevance and detectable first at higher ages, which gives us further insight to the complex regulation of TL. Genet. Epidemiol. 36:368-372, 2012. (c) 2012 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
Malden: Wiley-Blackwell, 2012. Vol. 36, no 4, 368-372 p.
Keyword [en]
telomere length, hTERT, hTERC, genotypes, cancer
National Category
Genetics Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-55669DOI: 10.1002/gepi.21630ISI: 000303319900009OAI: oai:DiVA.org:umu-55669DiVA: diva2:529444
Available from: 2012-05-30 Created: 2012-05-28 Last updated: 2017-12-07Bibliographically approved

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Melin, Beatrice S.Andersson, UlrikaRoos, Göran

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