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Mucosal lichen planus, a systemic disease requiring multidisciplinary care: a cross-sectional clinical review from a multidisciplinary perspective
Umeå University, Faculty of Medicine, Department of Odontology, Endodontics. Umeå University, Faculty of Medicine, Department of Odontology, Oral Diagnostics.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
2012 (English)In: Journal of Lower Genital Tract Disease, ISSN 1089-2591, E-ISSN 1526-0976, Vol. 16, no 4, 377-380 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study aimed to emphasize the importance of seeing mucosal lichen planus (LP) as a systemic disease and not an isolated oral or genital disease and to analyze the proportion of thyroid antibodies among patients with multimucosal LP.

MATERIALS AND METHODS: All patients examined by the authors and diagnosed with mucosal LP within 1 year were consecutively included. Full medical histories were collected with special emphasis on autoimmune and thyroid diseases. Sera were analyzed for thyroid antibodies and underwent serologic test for herpes virus. The control group comprised 83 healthy volunteers matched regarding sex and age.

RESULTS: Of the patients, 120 were included, 89 (74%) of whom were women and 31 (26%) were men. The vast majority of the patients had multifocal lesions, whereas oral lesions solely were found in 28% of women and 36% of men. Of the patients, 28% had at least 1 additional autoimmune disease. Approximately half of the women were treated with levothyroxine owing to thyroid disease. Antibodies against herpes simplex virus were found in 60% of the patients and 44% of the controls (p < .03).

CONCLUSIONS: Lichen planus with mucosal involvement should be considered and taken care of as a systemic disease and not as an isolated oral and/or genital lichen. Contradictory to many former reports, most of our patients have a multimucosal disease that emphasizes the need for a multidisciplinary clinic to get optimal care and treatment.

Place, publisher, year, edition, pages
2012. Vol. 16, no 4, 377-380 p.
National Category
Dentistry Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:umu:diva-55770DOI: 10.1097/LGT.0b013e318247a907ISI: 000309326200008PubMedID: 22622344OAI: oai:DiVA.org:umu-55770DiVA: diva2:529555
Available from: 2012-05-30 Created: 2012-05-30 Last updated: 2017-12-07Bibliographically approved

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Ebrahimi, MajidLundqvist, LottaWahlin, Ylva BrittNylander, Elisabet

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Ebrahimi, MajidLundqvist, LottaWahlin, Ylva BrittNylander, Elisabet
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EndodonticsOral DiagnosticsDermatology and VenerologyDepartment of Odontology
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Journal of Lower Genital Tract Disease
DentistryDermatology and Venereal Diseases

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