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Anaplastic lymphoma kinase in human cancer
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Palmer)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Hallberg)
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Palmer)
2012 (English)In: Critical reviews in oncogenesis, ISSN 0893-9675, E-ISSN 2162-6448, Vol. 17, no 2, 123-143 p.Article in journal (Refereed) Published
Abstract [en]

The anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is now implicated in a wide range of human cancers. Results from recent clinical trials with ALK inhibitors provide promise for patients harboring oncogenic ALK lesions. This review will discuss our current understanding of ALK in human cancer and the implication of recent results for treatment.

Place, publisher, year, edition, pages
2012. Vol. 17, no 2, 123-143 p.
Keyword [en]
ALK, NSCLC, neuroblastoma, inhibitors, receptor tyrosine kinases, oncogene
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-55158PubMedID: 22471704OAI: oai:DiVA.org:umu-55158DiVA: diva2:530215
Available from: 2012-06-01 Created: 2012-05-09 Last updated: 2017-12-07Bibliographically approved

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Schonherr, ChristinaHallberg, BengtPalmer, Ruth

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