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Immunological alterations used to predict infections in response to strenuous physical training
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Sports Medicine.
2011 (English)In: Military medicine, ISSN 0026-4075, Vol. 176, no 7, 785-790 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to screen leukocyte cell surface markers to identify possible predictors for infection related to physical training. Ten healthy soldiers (mean age, 19.1; mean body mass, 77.4 kg; mean VO2 peak, 4.54 L min(-1)/58.6 mL min(-1) kg(-1)) were included. Blood samples were collected and number of infections recorded before and after a 6-day training course. White blood cell distributions and expression of surface receptors changed during training. Before training, expression of CD3 on CD8+ lymphocytes and percent CD8+CD3 lymphocytes was lower, whereas CD4/CD8 ratio was higher among subjects who failed compared to those who completed the training. A subclinical infection before the start of the military training may alter the CD4/CD8 ratio. Prediction of future infections may be possible from pre-exercise immunological status, findings useful in military settings and exercise, where sudden infections may result in severe consequences.

Place, publisher, year, edition, pages
AMSUS - Association of Military Surgeons of the U.S. , 2011. Vol. 176, no 7, 785-790 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-56350PubMedID: 22128720OAI: diva2:533698
Available from: 2012-06-14 Created: 2012-06-14 Last updated: 2012-08-15Bibliographically approved

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