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Placental exosome-mediated immune protection of the fetus: feeling groovy in a cloud of exosomes
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Immunology. (Mincheva-Nilsson)
2010 (English)In: Expert Review of Obstetrics & Gynecology, ISSN 1747-4108, Vol. 5, no 5, 619-634 p.Article, review/survey (Refereed) Published
Abstract [en]

Exosomes are nanosized membrane-bound microvesicles that originate from the endosomal compartment and convey cell-cell contact “by proxy” transporting signals/packages of information between donor and recipient cells locally or/and at a distance. Exosomes are produced by a variety of immune, epithelial and tumor cells. Upon contact, exosomes transfer molecules that can render new properties and/or reprogram the recipient cells. Recently, it was discovered that the syncytiotrophoblast of human placenta continuously and constitutively secretes exosomes throughout pregnancy. These exosomes, delivered directly in the maternal blood surrounding the chorionic villi of the placenta, are immunosuppressive and pluripotent carrying proteins, mRNA and microRNA that can influence a number of biologic mechanisms and promote the fetal allograft survival. The current knowledge about placental exosomes and their role in pregnancy is summarized and discussed in this article.

Place, publisher, year, edition, pages
Expert Reviews LTD , 2010. Vol. 5, no 5, 619-634 p.
Keyword [en]
placenta, exosomer, reproduktionsimmunologi
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
URN: urn:nbn:se:umu:diva-56448DOI: 10.1586/EOG.10.43OAI: diva2:534749
Available from: 2012-06-25 Created: 2012-06-18 Last updated: 2012-06-25Bibliographically approved

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