The gut microbiota regulates bone mass in mice
2012 (English)In: Journal of Bone and Mineral Research, ISSN 0884-0431, E-ISSN 1523-4681, Vol. 27, no 6, 1357-1367 p.Article in journal (Refereed) Published
The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ-free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV-R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV-R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast-mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. (C) 2012 American Society for Bone and Mineral Research.
Place, publisher, year, edition, pages
2012. Vol. 27, no 6, 1357-1367 p.
germ free, osteoporosis, osteoimmunology, serotonin, bone metabolism
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:umu:diva-56413DOI: 10.1002/jbmr.1588ISI: 000304141500013OAI: oai:DiVA.org:umu-56413DiVA: diva2:535230