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Solid organ transplantation for non-TTR hereditary amyloidosis: report from the 1st International Workshop on the Hereditary Renal Amyloidoses
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2012 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 19, no S1, 81-84 p.Article in journal (Refereed) Published
Abstract [en]

Fibrinogen A alpha-chain (AFib) and apolipoprotein AI (AApoAI) amyloidosis due to variants in the AFib and ApoAI genes are the most common types of hereditary amyloidosis in Europe and the United States. Liver is the exclusive source of the aberrant amyloidogenic protein in AFib and responsible for supplying approximately half of the circulating variant ApoAI. Nephrotic syndrome and renal impairment due to renal amyloidosis are common disease manifestations; however, recent research provides evidence to support a more diverse and systemic disease phenotype, which in turn has implications in the management of the hereditary amyloidoses with solid organ transplantation and, in particular, liver transplantation.

Place, publisher, year, edition, pages
2012. Vol. 19, no S1, 81-84 p.
Keyword [en]
Amyloidosis, apolipoprotein AI, domino, fibrinogen A alpha-chain, non-TTR, preemptive transplant, transplantation
National Category
Family Medicine
Identifiers
URN: urn:nbn:se:umu:diva-56407DOI: 10.3109/13506129.2012.668503ISI: 000304406400029OAI: oai:DiVA.org:umu-56407DiVA: diva2:535562
Available from: 2012-06-20 Created: 2012-06-18 Last updated: 2017-12-07Bibliographically approved

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Suhr, Ole

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