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Does ketoprofen or diclofenac pose the lowest risk to fish?
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2012 (English)In: Journal of Hazardous Materials, ISSN 0304-3894, E-ISSN 1873-3336, Vol. 229-230, 100-106 p.Article in journal (Refereed) Published
Abstract [en]

Ketoprofen and diclofenac are non-steroidal anti-inflammatory drugs (NSAIDs) often used for similar indications, and both are frequently found in surface waters. Diclofenac affects organ histology and gene expression in fish at around 1μg/L. Here, we exposed rainbow trout to ketoprofen (1, 10 and 100μg/L) to investigate if this alternative causes less risk for pharmacological responses in fish. The bioconcentration factor from water to fish blood plasma was <0.05 (4 for diclofenac based on previous studies). Ketoprofen only reached up to 0.6‰ of the human therapeutic plasma concentration, thus the probability of target-related effects was estimated to be fairly low. Accordingly, a comprehensive analysis of hepatic gene expression revealed no consistent responses. In some contrast, trout exposed to undiluted, treated sewage effluents bioconcentrated ketoprofen and other NSAIDs much more efficiently, according to a meta-analysis of recent studies. Neither of the setups is however an ideal representation of the field situation. If a controlled exposure system with a single chemical in pure water is a reasonable representation of the environment, then the use of ketoprofen is likely to pose a lower risk for wild fish than diclofenac, but if bioconcentration factors from effluent-exposed fish are applied, the risks may be more similar.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 229-230, 100-106 p.
National Category
Chemical Sciences
URN: urn:nbn:se:umu:diva-56748DOI: 10.1016/j.jhazmat.2012.05.077PubMedID: 22721833OAI: diva2:537315
Available from: 2012-06-26 Created: 2012-06-26 Last updated: 2013-06-14Bibliographically approved

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Fick, Jerker
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