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Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans
Umeå University, Faculty of Medicine, Department of Odontology, Molecular Periodontology.
2012 (English)In: BMC Research Notes, ISSN 1756-0500, Vol. 5, 203- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Aggregatibacter actinomycetemcomitans produces a leukotoxin that activates a pro-inflammatory death of human monocytes/macrophages. A specific clone of this bacterium (JP2) has a 530-base pair deletion in the leukotoxin promoter gene that causes a significantly enhanced expression of leukotoxin. This specific clone of A. actinomycetemcomitans is common in some African populations and has a strong association with periodontal attachment loss in adolescents in these populations. Chewing sticks of plant origin are commonly used as oral hygiene tool in Africa, but their role as a therapeutic agent in periodontal disease is poorly investigated. RESULTS: Ethanol extracts were made from 7 common plants used as chewing sticks in West-Africa. None of the tested extracts inhibited growth of A. actinomycetemcomitans. However, extracts from Psidium guajava (Guava) completely neutralized the cell death and pro-inflammatory response of human leukocytes induced by the leukotoxin. None of the six other tested chewing stick extracts showed this effect. CONCLUSIONS: The discovery that extracts from Guava efficiently neutralizes A. actinomycetemcomitans leukotoxicity might lead to novel therapeutic agents and strategies for prevention and treatment of aggressive forms of periodontitis induced by infections with the highly leukotoxic JP2 clone of this bacterium.

Place, publisher, year, edition, pages
BioMed Central, 2012. Vol. 5, 203- p.
Keyword [en]
Leukotoxin, Guava
National Category
Research subject
Pharmaceutical Microbiology; Odontology
URN: urn:nbn:se:umu:diva-56822DOI: 10.1186/1756-0500-5-203PubMedID: 22537711OAI: diva2:537697
Available from: 2012-06-27 Created: 2012-06-27 Last updated: 2012-08-09Bibliographically approved

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