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Adenovirus receptors: implications for targeting of viral vectors
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
2012 (Engelska)Ingår i: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 33, nr 8, s. 442-448Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Cancer, cardiovascular disease, and infectious diseases are all global health threats. To combat these diseases with gene therapies, adenovirus-based vectors have been developed. Although certain clinical trials appear successful, there is an obvious need to improve the efficacy of most adenovirus-based vectors. For the most commonly used vector (based on type 5; Ad5), a main problem is its accumulation in the liver, which can be attributed to interactions with specific host factors. The diverse tropism for types other than Ad5 implies that vectors based on alternative types could have advantages. The numerous interactions of different adenoviruses with host molecules - such as the recently identified desmoglein-2 receptor - may cause novel and unexpected obstacles, but also may provide possibilities for vectors based on alternative types. This review provides an update of new and previously known molecules that mediate cellular attachment of human adenoviruses and discusses how these may influence the targeting of adenovirus-based vectors.

Ort, förlag, år, upplaga, sidor
Elsevier, 2012. Vol. 33, nr 8, s. 442-448
Nationell ämneskategori
Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:umu:diva-56874DOI: 10.1016/j.tips.2012.04.005PubMedID: 22621975OAI: oai:DiVA.org:umu-56874DiVA, id: diva2:537948
Tillgänglig från: 2012-06-28 Skapad: 2012-06-28 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Arnberg, Niklas

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