Management of postpolio syndrome
2010 (English)In: Lancet Neurology, ISSN 1474-4422, E-ISSN 1474-4465, Vol. 9, no 6, 634-642 p.Article in journal (Refereed) Published
Postpolio syndrome is characterised by the exacerbation of existing or new health problems, most often muscle weakness and fatigability, general fatigue, and pain, after a period of stability subsequent to acute polio infection. Diagnosis is based on the presence of a lower motor neuron disorder that is supported by neurophysiological findings, with exclusion of other disorders as causes of the new symptoms. The muscle-related effects of postpolio syndrome are possibly associated with an ongoing process of denervation and reinnervation, reaching a point at which denervation is no longer compensated for by reinnervation. The cause of this denervation is unknown, but an inflammatory process is possible. Rehabilitation in patients with postpolio syndrome should take a multiprofessional and multidisciplinary approach, with an emphasis on physiotherapy, including enhanced or individually modified physical activity, and muscle training. Patients with postpolio syndrome should be advised to avoid both inactivity and overuse of weak muscles. Evaluation of the need for orthoses and assistive devices is often required.
Place, publisher, year, edition, pages
The Lancet Publishing Group , 2010. Vol. 9, no 6, 634-642 p.
randomized controlled trial, 4-year follow-up, quality of life, placebo-controlled trial, former polio patients, late-onset sequelae, muscle strength, prior poliomyelitis, intravenous immunoglobulin, motor units
IdentifiersURN: urn:nbn:se:umu:diva-57017DOI: 10.1016/S1474-4422(10)70095-8ISI: 000278512000016PubMedID: 20494327OAI: oai:DiVA.org:umu-57017DiVA: diva2:538828