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The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2012 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 38, no 1, 160-168 p.Article in journal (Refereed) Published
Abstract [en]

Zizimin-related (Zir), a Rho guanine nucleotide exchange factor (RhoGEF) homologous to the mammalian Dock-C/Zizimin-related family, was identified in a screen to find new genes involved in the Drosophila melanogaster cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. RhoGEFs activate Rho-family GTPases, which are known to be central regulators of cell migration, spreading and polarity. When a parasitoid wasp is recognized as foreign, multiple layers of circulating immunosurveillance cells (haemocytes) should attach to the egg. In Zir mutants this process is disrupted and lamellocytes, a haemocyte subtype, fail to properly encapsulate the wasp egg. Furthermore, macrophage-like plasmatocytes exhibit a strong reduction in their ability to phagocytise Escherichia coli and Staphylococcus aureus bacteria. During encapsulation and phagocytosis Zir genetically interacts with two Rho-family GTPases, Rac2 and Cdc42. Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 38, no 1, 160-168 p.
National Category
Basic Medicine Biological Sciences
URN: urn:nbn:se:umu:diva-57094DOI: 10.1016/j.dci.2012.05.004PubMedID: 22634526OAI: diva2:539700
Available from: 2012-07-04 Created: 2012-07-04 Last updated: 2012-10-18Bibliographically approved

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Hultmark, Dan
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Department of Molecular Biology (Faculty of Medicine)
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