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Twenty-five years of deep brain stimulation: Celebrations and apprehensions
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2012 (English)In: Movement Disorders, ISSN 0885-3185, E-ISSN 1531-8257, Vol. 27, no 7, 930-933 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

The year 2012 marks the 25th anniversary of the birth of modern deep brain stimulation (DBS), which was introduced by Benabid et al in 1987, initially to treat tremor with DBS of the ventral intermediate nucleus of the thalamus. The subsequent extension of DBS to the subthalamic nucleus (STN), demonstrating its efficacy on virtually all symptoms of advanced Parkinson's disease (PD), sparked an era of intense clinical and research activities, eventually transcending PD and movement disorders to encompass mood and mind. Investigations of the role of DBS in a variety of neurological, psychiatric, cognitive, and behavioral conditions is ongoing. Serendipitous discoveries and advances in functional imaging are providing new brain targets for an increasing number of pathologies. Toward the end of this quarter of a century of DBS, there have been some indications that the field may be at risk of gliding down a slippery slope, reminiscent of the excesses of the old-era DBS. Although there are many reasons this year to celebrate the achievements of 25 years of modern DBS, there are also reasons to fear the opening of a new Pandora's box.

Place, publisher, year, edition, pages
2012. Vol. 27, no 7, 930-933 p.
Keyword [en]
deep brain stimulation, history, Parkinson's disease, psychiatric illness, ethics
National Category
URN: urn:nbn:se:umu:diva-57372DOI: 10.1002/mds.25007ISI: 000305581900031OAI: diva2:541393
Available from: 2012-07-17 Created: 2012-07-16 Last updated: 2012-07-17Bibliographically approved

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Hariz, Marwan
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