umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
HbA(1c) Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus
Show others and affiliations
2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 6, e38877- p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Observational studies have shown that glycated haemoglobin (HbA(1c)) is related to mortality, but the shape of the association is less clear. Furthermore, disease duration and medication may modify this association. This observational study explored the association between HbA(1c) measured in stored erythrocytes and mortality. Secondly, it was assessed whether disease duration and medication use influenced the estimates or were independently associated with mortality. Methods: Within the European Prospective Investigation into Cancer and Nutrition a cohort was analysed of 4,345 individuals with a confirmed diagnosis of diabetes at enrolment. HbA(1c) was measured in blood samples stored up to 19 years. Multivariable Cox proportional hazard regression models for all-cause mortality investigated HbA(1c) in quartiles as well as per 1% increment, diabetes medication in seven categories of insulin and oral hypoglycaemic agents, and disease duration in quartiles. Results: After a median follow-up of 9.3 years, 460 participants died. Higher HbA(1c) was associated with higher mortality: Hazard Ratio for 1%-increase was 1.11 (95% CI 1.06, 1.17). This association was linear (P-nonlinearity = 0.15) and persistent across categories of medication use, disease duration, and co-morbidities. Compared with metformin, other medication types were not associated with mortality. Longer disease duration was associated with mortality, but not after adjustment for HbA(1c) and medication. Conclusion: This prospective study showed that persons with lower HbA(1c) had better survival than those with higher HbA(1c). The association was linear and independent of disease duration, type of medication use, and presence of co-morbidities. Any improvement of HbA(1c) appears to be associated with reduced mortality risk.

Place, publisher, year, edition, pages
2012. Vol. 7, no 6, e38877- p.
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-57363DOI: 10.1371/journal.pone.0038877ISI: 000305341900059OAI: oai:DiVA.org:umu-57363DiVA: diva2:541420
Available from: 2012-07-17 Created: 2012-07-16 Last updated: 2017-12-07Bibliographically approved

Open Access in DiVA

fulltext(961 kB)165 downloads
File information
File name FULLTEXT02.pdfFile size 961 kBChecksum SHA-512
07de0b044331f9a1597b56bce9d73f03d2c3b66eb0c36482ae85d8b6ba1d75db04da1307e321edcefb6744a1b106fc2e028b02c859244eafaf900303e1ce200c
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Franks, Paul W.Rolandsson, Olov
By organisation
MedicineNutritional ResearchFamily Medicine
In the same journal
PLoS ONE
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 165 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 57 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf