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Beneficial Effect of Interleukin 1 Inhibition with Anakinra in Adult-onset Still's Disease. An Open, Randomized, Multicenter Study
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2012 (English)In: Journal of Rheumatology, ISSN 0315-162X, E-ISSN 1499-2752, Vol. 39, no 10, 2008-2011 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study the efficacy of anakinra versus disease-modifying antirheumatic drugs (DMARD) in refractory adult-onset Still's disease (AOSD). METHODS: In a 24-week study, 22 patients with AOSD taking prednisolone ≥ 10 mg/day received anakinra (n = 12) or DMARD (n = 10). The primary endpoint was achievement of remission. RESULTS: At 8 and 24 weeks, 7/12 and 6/12 receiving anakinra and 5/10 and 2/10 receiving DMARD achieved remission. Anakinra induced greater improvement in physical health measured by Medical Outcomes Study Short-Form 36 (SF-36; p < 0.011). During an open-label extension (OLE) of 28 weeks, 7/14 patients taking anakinra and 2/3 taking DMARD were in remission. CONCLUSION: Anakinra induced more beneficial responses than DMARD in patients with AOSD and was favored in the OLE phase. ( Protocol Registration NCT01033656).

Place, publisher, year, edition, pages
2012. Vol. 39, no 10, 2008-2011 p.
Keyword [en]
adult-onset still's disease, anakinra, interleukin 1, randomized, multicenter, wissler's syndrome
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:umu:diva-57705DOI: 10.3899/jrheum.111549ISI: 000310256100016PubMedID: 22859346OAI: diva2:543798
Available from: 2012-08-09 Created: 2012-08-09 Last updated: 2012-12-04Bibliographically approved

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