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Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
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2011 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 22, no 6, 925-928 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored.

METHODS: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort.

RESULTS: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9 nmol/L, p-value = 0.01) than primiparous women.

CONCLUSION: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy.

Place, publisher, year, edition, pages
Springer Netherlands, 2011. Vol. 22, no 6, 925-928 p.
Keyword [en]
Acupuncture, exercise, hemostatic factor, insulin resistance, adipocyte size, plasminogen activator inhibitor 1
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-57944DOI: 10.1007/s10552-011-9752-5PubMedID: 21387179OAI: diva2:545988
Available from: 2012-08-22 Created: 2012-08-21 Last updated: 2012-08-22Bibliographically approved

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Grankvist, KjellLakso, Hans-ÅkeLundin, Eva
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