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Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
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2012 (English)In: Advances in Yersinia Research, New York: Springer, 2012, Vol. 954, 357-363 p.Chapter in book (Refereed)
Abstract [en]

Bacterial virulence systems are attractive targets for development of new antibacterial agents. Yersinia spp. utilize the type III secretion (T3S) system to secrete and translocate Yersinia outer proteins (Yop effectors) into the cytosol of the target cell and thereby overcome host defenses to successfully establish an infection. Thus, the Yop effectors constitute attractive targets for drug development. In the present study we apply small molecule screening to identify inhibitors of one of the secreted proteins YopH, a tyrosine phosphatase required for virulence. Characterization of seven inhibitors indicated that both competitive and noncompetitive inhibitors were identified with IC50 values of 6–20 μM.

Place, publisher, year, edition, pages
New York: Springer, 2012. Vol. 954, 357-363 p.
Series
Advances in experimental medicine and biology, ISSN 0065-2598 ; 954
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-57956DOI: 10.1007/978-1-4614-3561-7_43ISI: 000333327900044PubMedID: 22782782ISBN: 978-1-4614-3560-0 (print)ISBN: 978-1-4614-3561-7 (print)OAI: oai:DiVA.org:umu-57956DiVA: diva2:546514
Available from: 2012-08-23 Created: 2012-08-21 Last updated: 2017-01-09Bibliographically approved

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Eriksson, JonasGrundström, ChristinSauer-Eriksson, A ElisabethSauer, Uwe HWolf-Watz, HansElofsson, Mikael
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Department of ChemistryUmeå Centre for Microbial Research (UCMR)Department of Molecular Biology (Faculty of Science and Technology)Molecular Infection Medicine Sweden (MIMS)
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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