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Regulation of alternative sigma factor use
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Shingler)
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2011 (English)In: Annual Review of Microbiology, ISSN 0066-4227, E-ISSN 1545-3251, Vol. 65, 37-55 p.Article in journal (Refereed) Published
Abstract [en]

Alternative bacterial sigma factors bind the catalytic core RNA polymerase to confer promoter selectivity on the holoenzyme. The different holoenzymes are thus programmed to recognize the distinct promoter classes in the genome to allow coordinated activation of discrete sets of genes needed for adaptive responses. To form the holoenzymes, the different sigma factors must be available to compete for their common substrate (core RNA polymerase). This review highlights (a) the roles of antisigma factors in controlling the availability of alternative sigma factors and (b) the involvement of diverse regulatory molecules that promote the use of alternative sigma factors through subversion of the domineering housekeeping σ(70). The latter include the nucleotide alarmone ppGpp and small proteins (DksA, Rsd, and Crl), which directly target the transcriptional machinery to mediate their effects.

Place, publisher, year, edition, pages
Annual reviews , 2011. Vol. 65, 37-55 p.
National Category
Biochemistry and Molecular Biology Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-58140DOI: 10.1146/annurev.micro.112408.134219PubMedID: 21639785OAI: oai:DiVA.org:umu-58140DiVA: diva2:547043
Available from: 2012-08-27 Created: 2012-08-27 Last updated: 2017-12-07Bibliographically approved

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Österberg, Sofiadel Peso-Santos, TeresaShingler, Victoria
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