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DNA Polymerase ε
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
2012 (English)In: The eukaryotic replisome: a guide to protein structure and function / [ed] MacNeill S, Springer Science+Business Media B.V., 2012, Vol. 62, 237-57 p.Chapter in book (Refereed)
Abstract [en]

DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis. In this chapter, we will discuss the structure of Pol ε, the individual subunits and their function.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2012. Vol. 62, 237-57 p.
Series
Subcellular biochemistry, ISSN 0306-0225 ; 62
Keyword [en]
DNA replication, leading strand, pre-loading complex, processivity
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-58168DOI: 10.1007/978-94-007-4572-8_13PubMedID: 22918589ISBN: 9789400745728 (print)OAI: oai:DiVA.org:umu-58168DiVA: diva2:547132
Available from: 2012-08-27 Created: 2012-08-27 Last updated: 2015-08-14Bibliographically approved

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Hogg, MatthewJohansson, Erik

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