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Pitch variability in patients with Parkinson’s disease: effects of deep brain stimulation of caudal zona incerta and subthalamic nucleus
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurology.
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2013 (English)In: Journal of Speech, Language and Hearing Research, ISSN 1092-4388, E-ISSN 1558-9102, Vol. 56, no 1, 150-158 p.Article in journal (Refereed) Published
Abstract [en]

Objective The purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of con- nected speech in patients with Parkinson’s disease (PD).

Methods Sixteen patients were evaluated preoperatively and 12 months after DBS surgery. Eight pa- tients were implanted in the STN (aged 51-72 yrs; xC=63 yrs). Six received bilateral implanta- tion and two unilateral (left) implantation. Eight patients were bilaterally implanted in the cZi (aged 49-71 yrs; xC=60.8 yrs). Preoperative assessments were made after an L-Dopa challenge (approximately 1.5 times the ordinary dose). All postoperative examinations were made off and on stimulation, with a clinically optimized dose of L-dopa. Measurements of pitch range and var- iability were obtained from each utterance in a recorded read speech passage.

Results Pitch range and coefficient of variation showed an increase in patients under STN-DBS. Patients under cZi-DBS showed no significant effects of treatment on investigated pitch properties.

Conclusions STN-DBS was shown to increase pitch variation and range. The results provided no evidence of cZi-DBS having a beneficial effect on PD patients’ pitch variability. 

Place, publisher, year, edition, pages
American Speech-Language-Hearing Association, 2013. Vol. 56, no 1, 150-158 p.
National Category
Neurology Otorhinolaryngology
Research subject
Linguistics; Neurology; Neurosurgery; Oto-Rhino-Laryngology
Identifiers
URN: urn:nbn:se:umu:diva-58210DOI: 10.1044/1092-4388(2012/11-0333)ISI: 000322444900012OAI: oai:DiVA.org:umu-58210DiVA: diva2:547275
Projects
En kontrastiv och longitudinell studie gällande effekten av djup hjärnstimulering på Parkinsons-patienters artikulatoriska förmåga.Intonation och rytm i talet hos personer med Parkinsons sjukdom - en longitudinell jämförelse mellan sjukdomens effekter och effekter av behandling
Funder
Swedish Research Council, 2009-946Swedish Research Council, 2011-2294
Available from: 2012-08-28 Created: 2012-08-27 Last updated: 2017-12-07Bibliographically approved

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Karlsson, FredrikOlofsson, KatarinaBlomstedt, PatricLinder, JanDoorn, Jan van
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