Novel cluster of alpha-interferon gene sequences in a placental cosmid DNA library.
1984 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 81, no 8, 2435-9 p.Article in journal (Refereed) Published
A human cosmid library was constructed and probed with a human alpha interferon (IFN-alpha) cDNA clone. One clone giving a strong hybridizing signal was isolated and characterized. The cosmid DNA insert represents a section of the human genome containing three regions of IFN-alpha-like sequences. The DNA was characterized with restriction endonuclease mapping, thereby allowing comparison to similar linkage groups reported recently and determination of homologous regions on the known physical map. The three IFN-alpha-like sequences were analyzed by a partial sequence analysis. Mapping and sequence data establish this section as a not-yet-described cluster of IFN-alpha sequences in the human genome; however, a part of the section matches to some degree to a previously described genomic region. The region described here could represent genetic polymorphism or a duplicated segment.
Place, publisher, year, edition, pages
1984. Vol. 81, no 8, 2435-9 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-59760PubMedID: 6326127OAI: oai:DiVA.org:umu-59760DiVA: diva2:556434