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Hormonal regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 gene expression in cultured mouse Sertoli cells.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
1993 (English)In: Science in China. Series B, Chemistry, life sciences & earth sciences, ISSN 1001-652X, Vol. 36, no 3, 319-328 p.Article in journal (Refereed) Published
Abstract [en]

We have demonstrated for the first time that (i) mouse Sertoli cells predominantly secrete tPA under the action of FSH and cAMP-generating agents, whereas Leydig cells mainly produce uPA; (ii) Sertoli cells are also capable of secreting PAI-1, as well as FSH, growth factors and GnRH increase PAI-1 gene expression; (iii) the increases in tPA and PAI-1 activities by different hormones in the conditioned media of Sertoli cells correspond to the increases in the levels of tPA and PAI-1 mRNA in the cultured cells, suggesting that the synthesis of the activator-inhibitor in mouse Sertoli cells is regulated at a transcriptional level and the tPA secreted by Sertoli cells may be involved in the spermatogenesis.

Place, publisher, year, edition, pages
1993. Vol. 36, no 3, 319-328 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-59986PubMedID: 8397803OAI: diva2:557316
Available from: 2012-09-27 Created: 2012-09-27 Last updated: 2012-11-28Bibliographically approved

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