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Myocardial infarction in relation to mercury and fatty acids from fish: a risk-benefit analysis based on pooled Finnish and Swedish data in men
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. (Arcum)
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. (Arcum)
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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2012 (Engelska)Ingår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 96, nr 4, s. 706-713Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Exposure to methylmercury from fish has been associated with increased risk of myocardial infarction (MI) in some studies. At the same time, marine n-3 (omega-3) PUFAs are an inherent constituent of fish and are regarded as beneficial. To our knowledge, no risk-benefit model on the basis of data on methylmercury, PUFA, and MI risk has yet been presented.

Objective: The objective of this study was to describe how exposure to both marine n-3 PUFAs and methylmercury relates to MI risk by using data from Finland and Sweden.

Design: We used matched case-control sets from Sweden and Finland that were nested in population-based, prospective cohort studies. We included 361 men with MI from Sweden and 211 men with MI from Finland. MI risk was estimated in a logistic regression model with the amount of mercury in hair (hair-Hg) and concentrations of n-3 PUFAs (EPA and DHA) in serum (S-PUFA) as independent variables.

Results: The median hair-Hg was 0.57 mu g/g in Swedish and 1.32 mu g/g in Finnish control subjects, whereas the percentage of S-PUFA was 4.21% and 3.83%, respectively. In combined analysis, hair-Hg was associated with higher (P = 0.005) and S-PUFA with lower (P = 0.011) MI risk. Our model indicated that even a small change in fish consumption (ie, by increasing S-PUFA by 1%) would prevent 7% of MIs, despite a small increase in mercury exposure. However, at a high hair-Hg, the modeled beneficial effect of PUFA on MI risk was counteracted by methylmercury.

Conclusions: Exposure to methylmercury was associated with increased risk of MI, and higher S-PUFA concentrations were associated with decreased risk of MI. Thus, MI risk may be reduced by the consumption of fish high in PUFAs and low in methylmercury.

Am J Clin Nutr 2012;96:706-13.

Ort, förlag, år, upplaga, sidor
2012. Vol. 96, nr 4, s. 706-713
Nationell ämneskategori
Kardiologi Arbetsmedicin och miljömedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-61169DOI: 10.3945/ajcn.111.033795ISI: 000308977000005OAI: oai:DiVA.org:umu-61169DiVA, id: diva2:566777
Tillgänglig från: 2012-11-09 Skapad: 2012-11-07 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Wennberg, MariaBergdahl, Ingvar AJansson, Jan-HåkanNorberg, Margareta

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Wennberg, MariaBergdahl, Ingvar AJansson, Jan-HåkanNorberg, Margareta
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Yrkes- och miljömedicinMedicinEpidemiologi och global hälsa
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American Journal of Clinical Nutrition
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