Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
1996 (English)In: Infection and Immunity, ISSN 0019-9567, E-ISSN 1098-5522, Vol. 64, no 3, 829-35 p.Article in journal (Refereed) Published
The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
Place, publisher, year, edition, pages
1996. Vol. 64, no 3, 829-35 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-61472PubMedID: 8641788OAI: oai:DiVA.org:umu-61472DiVA: diva2:567997