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Yersinia invasin, a bacterial beta1-integrin ligand, is a potent inducer of lymphocyte motility and migration to collagen type IV and fibronectin.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
1997 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 159, no 4, 1853-9 p.Article in journal (Refereed) Published
Abstract [en]

The Yersinia pseudotuberculosis invasin protein was found to be a potent inducer of pseudopodia formation and chemotactic and haptotactic migration in human T lymphocytes. Checkerboard analysis confirmed that migration was directional. The Yersinia invasin triggered migration of otherwise poorly migratory normal T cells on fibronectin and in particular on collagen type IV, and augmented the migration of leukemic T cell lines on these components. Invasin-induced lymphocyte migration was inhibited by staurosporin that selectively prevented pseudopodia formation but, noteworthy, augmented adhesion. The motogenic and attractant properties of invasin (Inv) were mediated via beta1-integrins, as shown by lack of effect of Inv on the motility of a beta1-integrin-negative lymphoid cell line and inhibition of invasin-induced lymphocyte motility by anti-beta1 Abs. Inv was markedly more effective than the extracellular matrix components fibronectin, collagen type IV, and laminin, which also interact with lymphocyte beta1-integrins, with respect to induction of pseudopodia, chemotaxis, and haptotaxis. Thus, Yersinia invasin is a model ligand for induction of lymphocyte motility via beta1-integrins. The extraordinary capacity of Inv to trigger and guide T lymphocyte motility and potentiate lymphocyte migration to extracellular matrix components may be of pathogenetic significance for the movement of lymphocytes to extraintestinal sites secondary to Yersinia infection.

Place, publisher, year, edition, pages
1997. Vol. 159, no 4, 1853-9 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-61475PubMedID: 9257849OAI: oai:DiVA.org:umu-61475DiVA: diva2:568001
Available from: 2012-11-15 Created: 2012-11-15 Last updated: 2017-12-07
In thesis
1. Interactions between Yersinia pseudotuberculosis and host cells - role of invasin and YopH
Open this publication in new window or tab >>Interactions between Yersinia pseudotuberculosis and host cells - role of invasin and YopH
1999 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 1999. 72 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 634
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-65079 (URN)91-7191-732-2 (ISBN)
Public defence
Föreläsningssalen, Institutionen för mikrobiologi, Umeå universitet, Umeå (English)
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retroaktiv registrering

Available from: 2013-02-06 Created: 2013-02-05 Last updated: 2013-02-06Bibliographically approved

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