No link between rosacea and Propionibacterium acnes
2012 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 120, no 11, 922-925 p.Article in journal (Refereed) Published
Rosacea is a common skin disease in adults affecting mainly the facial skin. Although inflammation appears to play a pathogenic role in rosacea, initiating factors are largely unknown. Microbial involvement in the development of rosacea has been suggested previously. We aimed to visualize Propionibacterium acnes in the skin compartments of rosacea patients. Facial skin biopsies from 82 rosacea patients and 25 controls were stained with a P. acnes-specific monoclonal antibody (QUBPa3). Seven of 82 patients (8.5%) tested positive for P. acnes which was present either as a biofilm (57% of positive) or a microcolony (43%) in colonized patients. Our results suggest that P. acnes does not play a major role in the pathogenesis of rosacea.
Place, publisher, year, edition, pages
2012. Vol. 120, no 11, 922-925 p.
Propionibacterium acnes, rosacea, immunofluorescence, biofilm, granuloma
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-61150DOI: 10.1111/j.1600-0463.2012.02920.xISI: 000309182900007OAI: oai:DiVA.org:umu-61150DiVA: diva2:568096