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Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
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2012 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 66, no 10, 1082-1092 p.Article, review/survey (Refereed) Published
Abstract [en]

Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.

Place, publisher, year, edition, pages
London: Nature Publishing Group, 2012. Vol. 66, no 10, 1082-1092 p.
Keyword [en]
fruit, vegetables, type 2 diabetes mellitus, epidemiology, meta-analysis, review
National Category
Nutrition and Dietetics
URN: urn:nbn:se:umu:diva-61563DOI: 10.1038/ejcn.2012.85ISI: 000309646100003OAI: diva2:572545
Available from: 2012-11-28 Created: 2012-11-20 Last updated: 2012-11-28Bibliographically approved

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Franks, Paul W.Rolandsson, Olov
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