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Reoperation after failed deep brain stimulation for essential tremor
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
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2012 (English)In: World Neurosurgery, ISSN 1878-8750, Vol. 78, no 5, 554.e1-554.e5 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To evaluate the effects of reoperation with deep brain stimulation (DBS) in the caudal zona incerta (cZi) in patients with failed DBS in the ventral intermediate (Vim) nucleus of the thalamus for essential tremor. METHODS: The results of reoperation with cZi DBS in five patients with failed Vim DBS were retrospectively analyzed. RESULTS: Two patients had early failure of Vim DBS, and three after several years of good effect. The mean deviation from the atlas Vim target point was 1.4 mm. Before the reoperation Vim DBS improved hand function and tremor in the treated hand at 25 %, whereas cZi DBS achieved an improvement of 57%. Although cZi was more efficient than Vim DBS, also in the patients with late failure of Vim DBS, they still exhibited a considerable residual tremor on cZi DBS. CONCLUSIONS: The effect on tremor was, in this small sample population, improved by implanting an electrode in the cZi. The effect was modest in those patients suffering a deterioration years after the initial operation.

Place, publisher, year, edition, pages
Elsevier, 2012. Vol. 78, no 5, 554.e1-554.e5 p.
Keyword [en]
DBS, Posterior subthalamic area, Tremor, Vim, Zona incerta
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-63776DOI: 10.1016/j.wneu.2011.12.013ISI: 000311996100043OAI: oai:DiVA.org:umu-63776DiVA: diva2:586568
Available from: 2013-01-11 Created: 2013-01-07 Last updated: 2013-01-11Bibliographically approved

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Blomstedt, PatricLindvall, PeterLinder, JanOlivecrona, MagnusForsgren, LarsHariz, Marwan I.
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CiteExportLink to record
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