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Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2013 (English)In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 32, no 3, 577-584 p.Article in journal (Refereed) Published
Abstract [en]

The Patancheru area near Hyderabad in India is recognized as a key link in the global supply chain for many bulk drugs. A central treatment plant receives wastewater from approximately 90 different manufacturers, and the resulting complex effluent has contaminated surface, ground, and drinking water in the region. Ecotoxicological testing of the effluent has shown adverse effects for several organisms, including aquatic vertebrates, at high dilutions. In addition, a recent study of microbial communities in river sediment indicated that the contamination of antibiotic substances might contribute to the emergence and spread of antibiotic resistance genes. In an attempt to start investigating how exposure to effluent-contaminated water may directly affect humans and other terrestrial vertebrates, rats were tube-fed effluent. Several pharmaceuticals present in the effluent could be detected in rat blood serum at low concentrations. However, results from exploratory microarray and quantitative polymerase chain reaction assays indicated no marked effects on hepatic gene transcription after 5 d of exposure. Neither did clinical analysis of blood serum constituents, used as biomarkers for human disease, reveal any significant changes, nor was there any weight gain. Taken together, the authors could not find evidence for any acute toxicity in the rat; however, the authors cannot rule out that higher doses of effluent or a longer exposure time may still be associated with risks for terrestrial vertebrates. Environ. Toxicol. Chem. © 2012 SETAC.

Place, publisher, year, edition, pages
2013. Vol. 32, no 3, 577-584 p.
Keyword [en]
Pharmaceutical production, Wastewater, Residual active pharmaceutical ingredient, Blood serum screening, Global hepatic gene expression
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-65786DOI: 10.1002/etc.2105PubMedID: 23258772OAI: oai:DiVA.org:umu-65786DiVA: diva2:604570
Note

Corrected by:

Erratum: Erratum: Oral exposure to industrial effluent with exceptionally high levels of drugs does not indicate acute toxic effects in rats

Vol. 32, Issue 4, 966, Article first published online: 18 MAR 2013

Available from: 2013-02-11 Created: 2013-02-11 Last updated: 2017-12-06Bibliographically approved

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Fick, Jerker

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