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The Synthetic Progestin Levonorgestrel is a Potent Androgen in the three-spined Stickleback (Gasterosteus aculeatus)
Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, SE-75 236 Uppsala, Sweden.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, SE-75 236 Uppsala, Sweden.
Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, SE-75 236 Uppsala, Sweden.
2013 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 47, no 4, 2043-2051 p.Article in journal (Refereed) Published
Abstract [en]

The use of progestins has resulted in contamination of aquatic environments and some progestins have in experimental studies been shown to impair reproduction in fish and amphibians at low ng L(-1) concentrations. The mechanisms underlying their reproductive toxicity are largely unknown. Some progestins, such as levonorgestrel (LNG), exert androgenic effects in mammals by activating the androgen receptor (AR). Male three-spined stickleback (Gasterosteus aculeatus) kidneys produce spiggin, a glue-like glycoprotein used in nest building, and its production is directly governed by androgens. Spiggin is normally absent in females but its production in female kidneys can be induced by AR agonists. Spiggin serves as the best known biomarker for androgens in fish. We exposed adult female sticklebacks to LNG at 5.5, 40 and 358 ng L(-1) for 21 days. Androgenic effects were found at LNG concentrations ≥40 ng L(-1) including induction of spiggin transcription, kidney hypertrophy and suppressed liver vitellogenin transcription. These are the first in vivo quantitative data showing that LNG is a potent androgen in fish, supporting the contention that androgenic effects of certain progestins contribute to their reproductive toxicity.

Place, publisher, year, edition, pages
2013. Vol. 47, no 4, 2043-2051 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-65785DOI: 10.1021/es304305kPubMedID: 23362984OAI: oai:DiVA.org:umu-65785DiVA: diva2:604571
Available from: 2013-02-11 Created: 2013-02-11 Last updated: 2017-12-06Bibliographically approved

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