Enantioselective synthesis of substituted piperidines by addition of aryl Grignard reagents to pyridine N-oxides
2013 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 15, no 1, 54-57 p.Article in journal (Refereed) Published
The synthesis of optically active piperidines by enantioselective addition of aryl Grignard reagents to pyridine N-oxides and lithium binolate followed by reduction is reported for the first time. The reaction results in high yields (51-94%) in combination with good ee (54-80%). Some of these products were subsequently recrystallized, affording enhanced optical purities (>99% ee).
Place, publisher, year, edition, pages
2013. Vol. 15, no 1, 54-57 p.
IdentifiersURN: urn:nbn:se:umu:diva-66115DOI: 10.1021/ol303085qPubMedID: 23256529OAI: oai:DiVA.org:umu-66115DiVA: diva2:605626