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Cerebral microvascular effects of nimodipine in combination with soman
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
FOI, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden.
FOI, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden.
2012 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, Vol. 34, no 3, 905-910 p.Article in journal (Refereed) Published
Abstract [en]

Nimodipine, a calcium antagonist, has been shown to increase the detoxification of soman. In this study the cerebral microcirculatory effects of nimodipine and the acetylcholinesterase inhibitor soman was studied. Anaesthetised rats were administered nimodipine, 10 mg kg(-1) or vehicle intra-peritoneally, and 1 h later exposed to 45 mu g kg(-1) soman intravenously. The regional blood flows were measured using the microsphere method. Nimodipine and soman markedly increased the cerebral blood flow (CBF) and reduced the vascular resistance. Total CBF increased by 146% after nimodipine and by 105% after soman administration. Combined administration of nimodipine and soman caused additional but not fully additive effects on CBF and vascular resistance, indicating possible different mechanisms of the two agents. A part of the nimodipine induced increased detoxification after AChE-inhibition may be associated with this cerebral vasodilation. (C) 2012 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2012. Vol. 34, no 3, 905-910 p.
Keyword [en]
Soman intoxication, Nimodipine, Regional cerebral blood flow, Microcirculation, Cerebral vasospasm
National Category
Pharmacology and Toxicology Neurosciences
URN: urn:nbn:se:umu:diva-66426DOI: 10.1016/j.etap.2012.08.008ISI: 000313463400032OAI: diva2:607364
Available from: 2013-02-22 Created: 2013-02-19 Last updated: 2013-02-22Bibliographically approved

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Koskinen, Lars-Owe D.
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