Cerebral microvascular effects of nimodipine in combination with soman
2012 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, Vol. 34, no 3, 905-910 p.Article in journal (Refereed) Published
Nimodipine, a calcium antagonist, has been shown to increase the detoxification of soman. In this study the cerebral microcirculatory effects of nimodipine and the acetylcholinesterase inhibitor soman was studied. Anaesthetised rats were administered nimodipine, 10 mg kg(-1) or vehicle intra-peritoneally, and 1 h later exposed to 45 mu g kg(-1) soman intravenously. The regional blood flows were measured using the microsphere method. Nimodipine and soman markedly increased the cerebral blood flow (CBF) and reduced the vascular resistance. Total CBF increased by 146% after nimodipine and by 105% after soman administration. Combined administration of nimodipine and soman caused additional but not fully additive effects on CBF and vascular resistance, indicating possible different mechanisms of the two agents. A part of the nimodipine induced increased detoxification after AChE-inhibition may be associated with this cerebral vasodilation. (C) 2012 Elsevier B.V. All rights reserved.
Place, publisher, year, edition, pages
2012. Vol. 34, no 3, 905-910 p.
Soman intoxication, Nimodipine, Regional cerebral blood flow, Microcirculation, Cerebral vasospasm
Pharmacology and Toxicology Neurosciences
IdentifiersURN: urn:nbn:se:umu:diva-66426DOI: 10.1016/j.etap.2012.08.008ISI: 000313463400032OAI: oai:DiVA.org:umu-66426DiVA: diva2:607364