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Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2013 (English)In: Current Opinion in Neurology, ISSN 1350-7540, E-ISSN 1473-6551, Vol. 26, no 1, 45-51 p.Article, review/survey (Refereed) Published
Abstract [en]

Purpose of review The discovery of a new class of intrinsically photosensitive retinal ganglion cells (ipRGCs) revealed their superior role for various nonvisual biological functions, including the pupil light reflex, and circadian photoentrainment. Recent findings Recent works have identified and characterized several anatomically and functionally distinct ipRGC subtypes and have added strong new evidence for the accessory role of ipRGCs in the visual system in humans. Summary This review summarizes current concepts related to ipRGC morphology, central connections and behavioural functions and highlights recent studies having clinical relevance to ipRGCs. Clinical implications of the melanopsin system are widespread, particularly as related to chronobiology.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 26, no 1, 45-51 p.
Keyword [en]
circadian rhythm, intrinsically photosensitive retinal ganglion cells, melanopsin, pupil, pupil light reflex
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-66401DOI: 10.1097/WCO.0b013e32835c5e78ISI: 000313547000007OAI: oai:DiVA.org:umu-66401DiVA: diva2:607414
Available from: 2013-02-22 Created: 2013-02-19 Last updated: 2017-12-06Bibliographically approved

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