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Prospective study on metabolic factors and risk of prostate cancer
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology.
Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden.
Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
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2012 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 118, no 24, 6199-6206 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer.

METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI); blood pressure; and blood levels of glucose, cholesterol, and triglycerides were collected for 289,866 men. Cox proportional hazard models were used to calculate relative risks (RRs) by exposures in quintiles as well as for z scores (with a mean of 0 and a standard deviation of 1) together with a composite sum of scores to assess the combined effect of metabolic factors. RRs were corrected for random errors in measurement.

RESULTS: During a mean follow-up of 12 years, 6673 men were diagnosed with prostate cancer and 961 died of the disease. Men with high levels of glucose and triglycerides were found to have a decreased risk of prostate cancer: top versus bottom quintile of glucose: RR, 0.82 (95% confidence interval [95% CI], 0.62-1.08; P value for trend = .03) and top versus bottom quintile of triglycerides: RR, 0.88 (95% CI, 0.74-1.04; P value for trend = .001). High BMI, elevated blood pressure, and a high composite z score were found to be associated with an increased risk of death from prostate cancer: top versus bottom quintile of BMI: RR, 1.36 (95% CI, 1.08-1.71); systolic blood pressure: RR, 1.62 (95% CI, 1.07-2.45); and per 1-unit increase of the composite z score: RR, 1.13 (95% CI, 1.03-1.25).

CONCLUSIONS: The authors found no evidence of an association between high levels of metabolic factors and the risk of prostate cancer, but high BMI, elevated blood pressure, and a composite score of all metabolic factors were associated with an increased risk of death from prostate cancer. 

Place, publisher, year, edition, pages
2012. Vol. 118, no 24, 6199-6206 p.
Keyword [en]
epidemiology, metabolic factors, prostate cancer, metabolic syndrome, cohort study, body mass index, blood pressure
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-64958DOI: 10.1002/cncr.27677ISI: 000311911600025OAI: oai:DiVA.org:umu-64958DiVA: diva2:608103
Available from: 2013-02-26 Created: 2013-02-04 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Metabolic factors and risk of prostate, kidney, and bladder cancer
Open this publication in new window or tab >>Metabolic factors and risk of prostate, kidney, and bladder cancer
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background: Prostate cancer is the most common cancer in Sweden with around 10,000 new cases every year. Kidney and bladder cancer are less common with 1,000 and 2,000 new cases annually, respectively. The incidence of these cancer sites is higher in developed, than in developing countries, suggesting an association between lifestyle and cancer risk. The aims of this thesis were to investigate body mass index (BMI), blood pressure, and blood levels of glucose, total cholesterol, and triglycerides as risk factors for prostate, kidney, and bladder cancer. Furthermore, we aimed at assess probabilities of prostate cancer and competing events, all-cause death, for men with normal and high levels of metabolic factors.

Material and methods: This thesis was conducted within the Metabolic Syndrome and Cancer project (Me-Can), a pooled cohort study with data from 578,700 participants from Norway, Sweden, and Austria. Data from metabolic factors were prospectively collected at health examinations and linked to the Cancer and Cause of Death registers in each country. 

Results: High levels of metabolic factors were not associated with increased risk of prostate cancer, but high levels of BMI and blood pressure were associated with risk of prostate cancer death. The probability of prostate cancer was higher for men with normal levels of metabolic factors compared to men with high levels, but the probability of all-cause death, was higher for men with high levels than for those with normal levels. For both men and women, high levels of metabolic factors were associated with increased risk of kidney cancer (renal cell carcinoma). Furthermore, blood pressure for men and BMI for women were found as independent risk factors of kidney cancer. High blood pressure was associated with an increased risk of bladder cancer for men.

Conclusions: High levels of metabolic factors were associated to risk of kidney and bladder cancer and to death from kidney, bladder, and prostate cancer. Compared to men with normal levels, men with high levels of metabolic factors had a decreased probability of prostate cancer but an increased probability of all-cause death.

Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2013. 58 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1612
Keyword
cohort study, competing risk, epidemiology, metabolic factors, prostate cancer, kidney cancer, bladder cancer, renal cell carcinoma, survival analysis
National Category
Urology and Nephrology
Research subject
Epidemiology; Urology; Oncology
Identifiers
urn:nbn:se:umu:diva-83947 (URN)978-91-7459-763-9 (ISBN)
Public defence
2014-01-24, Hörsal E04, byggnad 6E, Norrlands Universitetssjukhus, Umeå, 09:00 (English)
Opponent
Supervisors
Projects
Me-Can
Funder
Swedish Cancer Society, 2010/628
Note

Ytterligare forskningsfinansiärer: World Cancer Research Fund (2007/09) och Wereld Kanker Onderzoek Fonds (R2010/247)

Available from: 2013-12-17 Created: 2013-12-11 Last updated: 2014-01-15Bibliographically approved

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Häggstrom, ChristelStocks, TanjaHallmans, GöranJonsson, HåkanStattin, Pär
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