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Predictive factors of chronic kidney disease stage V after partial nephrectomy in a solitary kidney: a multi-institutional study
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2014 (English)In: Urologic Oncology, ISSN 1078-1439, E-ISSN 1873-2496, Vol. 32, no 1, 28.e21-28.e26 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Partial Nephrectomy (PN) in a solitary kidney is at risk of chronic kidney disease (CKD) stage V and/or haemodialysis (HD). Our objective was to determine predictive factors of CKD stage V in this population. MATERIAL & METHODS: Data from 300 patients were retrospectively collected from 16 tertiary centres. Clinical and operative parameters, tumor characteristics and renal function before surgery were analyzed. Patients with and without CKD stage V (defined as MDRD<15ml/min) were compared using χ2 and Student-t tests for qualitative and quantitative variables, respectively. Predictive factors of CKD stage V were evaluated with a multivariable analysis using a Cox regression model. RESULTS: Median age and BMI were 63 years old and 26kg/m², respectively. Most of the patients (65%) were male with an anatomic solitary kidney (88.3%). Median tumor size was 4cm and 98% were malignant tumors. Median operative time, blood loss and clamping time were 180min, 350ml and 20min respectively. Renal cooling was used in 19.3% and clamping of the pedicle was performed in 61.6%. Twenty five patients (8.5%) presented post operative CKD stage V at last follow-up and 18 underwent HD (6%) post-operatively because of acute renal insufficiency. There was no difference between CKD stage V and non CKD stage V patients concerning Charlson index, operative time (180min vs 179min, p= 0.39), blood loss (475ml vs 350ml, p= 0.51), use of renal cooling and type of clamping. Patients with CKD stage V were older (70 vs 63 years old, p= 0.005), had a lower baseline renal function (clearance MDRD 41 vs. 62ml/min, p<0.0001) and an increased tumor size (p= 0.02). Complications occurred in 91 patients (30%) with 16% of minor (Clavien 1-2) and 14% of major (Clavien>2) complications, respectively. In multivariable analysis, baseline MDRD, BMI, and the occurrence of a minor complication were independent predictive factors of post operative CKD stage V. CONCLUSION: PN in a solitary kidney is at risk of post-operative CKD stage V and HD. Pre-operative altered renal function and post operative complications are the main predictive factors of permanent CKD stage V.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 32, no 1, 28.e21-28.e26 p.
Keyword [en]
Renal cell carcinoma, Conservative surgery, Kidney cancer, Renal failure
National Category
Cancer and Oncology Urology and Nephrology
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URN: urn:nbn:se:umu:diva-66686DOI: 10.1016/j.urolonc.2012.10.003ISI: 000347243300020PubMedID: 23428536OAI: oai:DiVA.org:umu-66686DiVA: diva2:608289
Available from: 2013-02-27 Created: 2013-02-27 Last updated: 2017-12-06Bibliographically approved

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Ljungberg, Börje

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