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Intravascular haemolysis and increased prevalence of myeloma and monoclonal gammopathy in congenital dyserythropoietic anaemia, type III.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
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1994 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 52, no 1, 42-6 p.Article in journal (Refereed) Published
Abstract [en]

A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty-five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined significance (3 cases) and myeloma (1 case) among the patients.

Place, publisher, year, edition, pages
1994. Vol. 52, no 1, 42-6 p.
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Medical and Health Sciences
URN: urn:nbn:se:umu:diva-66825PubMedID: 8299769OAI: diva2:609408
Available from: 2013-03-05 Created: 2013-03-05 Last updated: 2013-03-05

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