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Polymer-based microfluidic devices for pharmacy, biology and tissue engineering
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics. Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
2012 (English)In: Polymers, ISSN 2073-4360, E-ISSN 2073-4360, Vol. 4, no 3, 1349-1398 p.Article, review/survey (Refereed) Published
Abstract [en]

This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.

Place, publisher, year, edition, pages
2012. Vol. 4, no 3, 1349-1398 p.
Keyword [en]
microfluidics, tissue engineering, biomedical engineering, polymers, biocompatibility, cell sorting, cell analysis, cell biology
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:umu:diva-65936DOI: 10.3390/polym4031349ISI: 000313357300002OAI: oai:DiVA.org:umu-65936DiVA: diva2:611981
Available from: 2013-03-19 Created: 2013-02-13 Last updated: 2017-12-06Bibliographically approved

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