Increased free androgen index is associated with hypertension in premenopausal women
2011 (English)In: Open Journal of Obstetrics and Gynecology, ISSN 2160-8792, E-ISSN 2160-8806, Vol. 1, 228-233 p.Article in journal (Refereed) Published
Objective: Increased testosterone and decreased sex hormone-binding globulin (SHBG) are associated with a number of adverse cardiovascular risk factors in postmenopausal women. The aim of this popula-tion-based study of women aged 25 to 50 was to as-sess the relationship between free androgen index (FAI) and cardiovascular risk factors in premeno-pausal women.
Methods: A population-based survey of 396 premenopausal women with no hormonal trea- tment was undertaken as part of the Northern Swe-den MONICA study. The study involved question-naires, anthropometry and assays of testosterone and SHBG.
Results: Increased FAI was associated with a number of cardiovascular risk factors in premeno-pausal women but this relationship was strongly af-fected by body mass index (BMI). After adjustment for age and BMI, FAI was significantly associated with increased systolic and diastolic blood pressures.
Conclusion: Hyperandrogenism is associated with increased blood pressure and these findings empha-size the need to assess cardiovascular risk factors in women with hyperandrogenism of all ages.
Place, publisher, year, edition, pages
Scientific Research Publishing, 2011. Vol. 1, 228-233 p.
Free Androgen Index, Blood Pressure
IdentifiersURN: urn:nbn:se:umu:diva-67507DOI: 10.4236/ojog.2011.14045OAI: oai:DiVA.org:umu-67507DiVA: diva2:612504