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Increased free androgen index is associated with hypertension in premenopausal women
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
2011 (English)In: Open Journal of Obstetrics and Gynecology, ISSN 2160-8792, E-ISSN 2160-8806, Vol. 1, 228-233 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Increased testosterone and decreased sex hormone-binding globulin (SHBG) are associated with a number of adverse cardiovascular risk factors in postmenopausal women. The aim of this popula-tion-based study of women aged 25 to 50 was to as-sess the relationship between free androgen index (FAI) and cardiovascular risk factors in premeno-pausal women.

Methods: A population-based survey of 396 premenopausal women with no hormonal trea- tment was undertaken as part of the Northern Swe-den MONICA study. The study involved question-naires, anthropometry and assays of testosterone and SHBG.

Results: Increased FAI was associated with a number of cardiovascular risk factors in premeno-pausal women but this relationship was strongly af-fected by body mass index (BMI). After adjustment for age and BMI, FAI was significantly associated with increased systolic and diastolic blood pressures.

Conclusion: Hyperandrogenism is associated with increased blood pressure and these findings empha-size the need to assess cardiovascular risk factors in women with hyperandrogenism of all ages.

Place, publisher, year, edition, pages
Scientific Research Publishing, 2011. Vol. 1, 228-233 p.
Keyword [en]
Free Androgen Index, Blood Pressure
National Category
Family Medicine
URN: urn:nbn:se:umu:diva-67507DOI: 10.4236/ojog.2011.14045OAI: diva2:612504
Available from: 2013-03-22 Created: 2013-03-22 Last updated: 2015-10-23Bibliographically approved

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