Change search
ReferencesLink to record
Permanent link

Direct link
pNfH is a promising biomarker for ALS
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Show others and affiliations
2013 (English)In: Amytrophic Lateral Sclerosis and Frontotemporal degeneration, ISSN 2167-8421, Vol. 14, no 2, 146-149 p.Article in journal (Refereed) Published
Abstract [en]

A diagnostic biomarker for ALS would permit early intervention with disease-modifying therapies while a biomarker for disease activity could accelerate the pace of drug discovery by facilitating shorter, and less costly, drug trials to be conducted with a smaller number of patients. Neurofilaments are the most abundant neuronal cytoskeletal protein. We set out to determine whether pNfH was a credible biomarker for ALS. pNfH levels were determined using an ELISA for 150 ALS subjects and 140 controls. We demonstrated a seven-fold elevation in the cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy subunit (pNfH) in ALS (median n = 2787 pg/ml, n = 150), compared to headache and other benign controls (3 (4 pg/ml, n = 100, p = < 0.05). There was a 10-fold elevation of pNfH compared to ALS mimics (266 pg/ml, n = 20) and other neurodegenerative and inflammatory conditions (27 (pg/ml for n = 20) which was also highly significant (p = < 0.05). pNfH achieved a diagnostic sensitivity of 90% and specificity of 87% in distinguishing ALS from all controls. We also detected an inverse correlation between CSF pNfH levels and disease duration (time from symptom onset to death, r(2) = 0.1247, p = 0.001). In conclusion, pNfH represents a promising candidate for inclusion in a panel of diagnostic and prognostic biomarkers.

Place, publisher, year, edition, pages
Informa Healthcare, 2013. Vol. 14, no 2, 146-149 p.
Keyword [en]
Neurofilament heavy chain, biomarker, amyotrophic lateral sclerosis
National Category
URN: urn:nbn:se:umu:diva-67791DOI: 10.3109/21678421.2012.729596ISI: 000315416500012OAI: diva2:614232
Available from: 2013-04-03 Created: 2013-04-03 Last updated: 2013-04-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Andersen, Peter M
By organisation
Clinical Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 42 hits
ReferencesLink to record
Permanent link

Direct link